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Study Measures Effects of Epinephrine on Prehospital Cardiac Arrest

2/25/2012

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A randomized double blind, placebo control trial looked at the effects of adrenaline (epinephrine) in prehospital cardiac arrest.The study measured survival to hospital discharge but also included a secondary analysis of return of spontaneous circulation (ROSC).
During the study period, a total of 534 patients were enrolled with 262 in the placebo group vs. 272 in the control group (adrenaline).
Investigators found those receiving adrenaline had 3.4 times great odds of achieving ROSC, and 2.2 great odds of survival to discharge.

Jacobs I, Finn J, Jelinek G, et al. Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomized double-blind placebo-controlled trial. Resuscitation. 2011;82(9):1138–1143.

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